Gastroenterology -Therapeutics & Hepatology

Liver Cirrhosis: New Therapies

Liver cirrhosis, a progressive liver disease characterized by fibrosis and loss of liver function, has traditionally been challenging to manage, often requiring liver transplantation in advanced cases. However, recent advances in therapy are offering new hope for patients. Innovative approaches in managing liver cirrhosis include novel pharmacological agents aimed at slowing or reversing fibrosis progression. For instance, antifibrotic drugs such as cenicriviroc and simtuzumab are undergoing trials to assess their efficacy in reducing liver scarring. Additionally, advancements in treatment for complications associated with cirrhosis, such as portal hypertension and ascites, include new interventional techniques and medications. Strategies like transjugular intrahepatic portosystemic shunt (TIPS) and new diuretics are improving patient outcomes. Lifestyle modifications and early intervention are also gaining importance, emphasizing the role of weight management, dietary changes, and the management of underlying conditions such as hepatitis. These new therapies are enhancing the quality of life and extending survival for individuals with liver cirrhosis.